Neurological Sciences and Neurophysiology

RESEARCH PAPER
Year
: 2020  |  Volume : 37  |  Issue : 1  |  Page : 11--17

Decision-making and impulse-control disorders in Parkinson's disease: Influence of dopaminergic treatment


Elif Yildirim1, Sibel Altinayar2, Raif Cakmur3 
1 Department of Psychology, Isik University, Istanbul, Turkey
2 Department of Neurology, School of Medicine, Inonu University, Malatya, Turkey
3 Department of Neurology, School of Medicine, Dokuz Eylul University, Izmir, Turkey

Correspondence Address:
Elif Yildirim
Department of Psychology, Isik University, Sile, Istanbul
Turkey

Objective: Dopaminergic treatment is proved to ameliorate motor deficits in Parkinson's disease (PD); however, it could have negative effects on behavior and cognition, including impulse controlling and decision-making. We aimed (1) to investigate the decision-making and impulse-control disorders (ICDs) of PD patients and their correlations with sociodemographical and clinical variables, dopaminergic treatment in particular, and (2) to determine the relation of decision-making with ICDs. Methods: The sample of 39 patients with PD and 37 healthy controls underwent cognitive tests and the task which analyzed decision-making (Iowa Gambling Task [IGT]). Besides assessing motor and nonmotor symptoms of patients with PD, ICDs were also scanned using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease. Results: Although patients with PD performed similarly to healthy controls on IGT, decision-making profile in PD related to clinical variables: dopaminergic treatment and duration of illness. In addition to this younger age of onset, higher dose of dopamine agonists, longer duration of illness, and impaired decision-making were together accounted for a substantial amount of variance in impulsive behaviors. Conclusions: Dopaminergic medication likely contributes to the impairment in decision-making, which may be the underlying mechanism of ICDs. Further studies will be necessary to understand the potential implications of this finding.


How to cite this article:
Yildirim E, Altinayar S, Cakmur R. Decision-making and impulse-control disorders in Parkinson's disease: Influence of dopaminergic treatment.Neurol Sci Neurophysiol 2020;37:11-17


How to cite this URL:
Yildirim E, Altinayar S, Cakmur R. Decision-making and impulse-control disorders in Parkinson's disease: Influence of dopaminergic treatment. Neurol Sci Neurophysiol [serial online] 2020 [cited 2020 Sep 26 ];37:11-17
Available from: http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2020;volume=37;issue=1;spage=11;epage=17;aulast=Yildirim;type=0